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The 2020 French Open continues on Friday morning with a men's semifinal between Novak Djokovic and Stefanos Tsitsipas at 11 a.m. ET. Djokovic is the No. 1 player in the world and Tistsipas is the No. 5 seed this year at Roland Garros. It's just the sixth time that the players have gone head-to-head. Djokovic holds the 3-2 edge in the series and beat Tsitsipas in straight sets the only time that they've played on clay last year in the finals of the Madrid Open.

However, Djokovic doesn't appear to be 100 percent and Tsitsipas moves incredibly well for his size at 6-foot-4. William Hill lists Djokovic as a -300 favorite (risk $300 to win $100) in the latest Djokovic vs. Tsitsipas odds, with the Greek getting +230 (risk $100 to win $230) as the underdog. The over-under for total games is 37.5, with Djokovic favored by 4.5 games. Before making any 2020 French Open picks, be sure to see the latest tennis predictions from SportsLine's Sean Calvert

Calvert is the famed handicapper who took down a huge score on Dominic Thiem winning Indian Wells at 80-1 last year, among many stunning calls. He's racked up seven straight profitable seasons betting tennis. 

At Wimbledon last year, Calvert told his followers to grab 3-1 odds on Novak Djokovic facing Roger Federer in the final, adding Djokovic would win it all. The result: Djokovic and Federer cruised into the finals, with Djokovic winning the longest men's singles final in tournament history. Anyone who followed Calvert's advice was handsomely rewarded.

Now, Calvert has locked in on the 2020 French Open men's semifinal matchup featuring Djokovic vs. Tsitsipas and revealed his best bets. Head to SportsLine to see them.

Djokovic vs. Tsitsipas preview

Calvert notes that Djokovic obviously wasn't himself in his win over Pable Carreno Busta on Wednesday, making this a challenging matchup pick an opponent he has a 3-2 career record against.

"For me this semifinal is much harder to form a strong opinion on than the Nadal/Schwartzman match, largely because we don't know what sort of condition Djokovic will be in," Calvert told SportsLine. "The world No. 1 struggled badly in the opening stages of his quarterfinal against Pablo Carreno Busta on Wednesday with a neck/shoulder injury that at one stage saw the pre-match -1250 favorite go to odds-against in-play.

"An opponent with more self-belief would surely have pushed Djokovic to his limit, but the Serb was able to raise his game and avoid using his backhand too much (his left arm was the issue), which was enough to see off Carreno Busta. Whether it will be enough to get the better of Tsitsipas remains to be seen."

How to make Djokovic vs. Tsitsipas picks

With Djokovic, ailing, Is Calvert calling for the big upset? The tennis guru has released confident picks on the outright winner, as well as a play on how long this semifinal lasts. Be sure to see Calvert's picks and analysis before locking in your French Open picks 2020 for the men's semifinals. 

Who wins Djokovic vs. Tsitsipas in the French Open 2020 men's semifinal? And what other pick could lead to a big return? Visit SportsLine now to see Sean Calvert's best bets for Djokovic vs. Tsitsipas, all from the famed tennis handicapper who's had seven straight profitable seasons.